Endothelial Signaling by Ig-Like Cell Adhesion Molecules

Endothelial Signaling by Ig-Like Cell Adhesion Molecules

The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events ...

Endothelial signalling by Ig-like cell adhesion molecules.

Leukocyte transendothelial migration is controlled by chemokine-induced signalling in leukocytes and integrin-ligand-induced bidirectional signalling in both leukocytes and endothelial cells. It is now generally accepted that endothelial signalling following leukocyte adhesion, serves to facilitate the crossing of the endothelium, be it via the paracellular or transcellular route. This brief ov...

Endothelial Cell Adhesion Molecules

Endothelial adhesion molecules play an important role in the tissue recruitment of leukocytes in inflammatory conditions such as rheumatoid arthritis. We have investigated the effect of the antirheumatic drug gold sodium thiomalate on adhesion molecule protein and mRNA expression in cultured human endothelial cells. Gold sodium thiomalate inhibited cytokine (TNF, IL-1, IL-4)-stimulated expressi...

Signaling by Ig - Like Transcript 2 Killer Cell Ig - Like Receptor - Dependent Sheryl

- 1 ) Signaling by Ig - Like Transcript 2 Killer Cell Ig - Like Receptor - Dependent